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Highlights

  • From these registers, we’ve learned valuable lessons about the powerful effects that the birth control pill can have on mood.
    • Note: “The researchers found that women on hormonal contraceptives were 50 percent more likely to be diagnosed with depression six months later, compared with women who were not prescribed hormonal contraceptives during this time.”

“They also found the women on hormonal contraceptives were 40 percent more likely to be prescribed an antidepressant than were women who weren’t prescribed hormonal contraceptives during this time.”

“The results of this study, as well as others, suggest the pill can increase some women’s risk of depression. This seemed particularly true for non-oral products (such as a patch, vaginal ring or hormonal IUD) and for young women (ages 15 to 19), whose brains are not yet done developing and may be more prone to the influence of hormonal signaling.”

  • The researchers found that women on hormonal contraceptives were 50 percent more likely to be diagnosed with depression six months later, compared with women who were not prescribed hormonal contraceptives during this time.
  • They also found the women on hormonal contraceptives were 40 percent more likely to be prescribed an antidepressant than were women who weren’t prescribed hormonal contraceptives during this time.
  • The results of this study, as well as others, suggest the pill can increase some women’s risk of depression. This seemed particularly true for non-oral products (such as a patch, vaginal ring or hormonal IUD) and for young women (ages 15 to 19), whose brains are not yet done developing and may be more prone to the influence of hormonal signaling.
  • As a scientist, I’m obliged to point out we don’t know for sure that the pills caused this increase. Correlation doesn’t equal causation.
  • For instance, women who seek medical interventions to prevent pregnancy might be more likely to seek medical interventions for depression.
  • However, the researchers statistically tested for the influence of a number of third variables, and each of these tests found that hormonal contraceptives predicted depression risk even after statistically controlling for these third variables.
  • The women on hormonal contraceptives were twice as likely to have attempted suicide during this time than the women not on hormonal contraceptives.
  • the risk of successful suicide attempts was actually higher: It was triple that of women not on hormonal contraceptives. As with depression risk, the biggest negative impact of hormonal contraceptives on suicide risk was found for young women (ages 15 to 19) on non-oral products.
  • When it comes to why the pill can mess with your mood, the two systems that shoulder most of the blame are the HPA axis and some of our neurotransmitter systems.
    • Note: hypothalamic-pituitary-adrenal axis
  • hypothalamic-pituitary-adrenal axis).